Caustic Esophageal Burns in Children and High Doses of Methylprednisolone

Phase 4CompletedNCT02002078

Sisli Hamidiye Etfal Training and Research Hospital83 enrolled

Overview

Corrosive substance ingestion in childhood is a public health issue in developing countries and several management protocols were proposed to prevent esophageal strictures. The role of corticosteroids in preventing corrosive-induced strictures is controversial. The investigators' aim is to study the influence of high doses of corticosteroids to prevent esophageal strictures.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Esophageal Diseases

Interventions

methylprednisolonDRUG

Eligibility

Sex: ALLMin age: 12 MonthsMax age: 17 Years

Medical Language ↔ Plain English

Inclusion Criteria: -Corrosive substance ingested children with grade IIb esophageal burn Exclusion Criteria: * Caustic substance ingested chldren grade I, IIa and grade III esophageal burns * Caustic subtance ingested children with signs of perforation, mediastinitis, peritonitis, sespis * Caustic substance ingested children with any chronic disease

Outcomes

Primary Outcomes

Evaluation of stricture development in children with caustic esophageal burns after high doses of methylprednisolone

stricture development was evaluated with endoscopic examination and upper gastrointestinal system series with barium swallow

Time frame: three years

Data from ClinicalTrials.gov

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