Carfilzomib With Bendamustine and Dexamethasone in Multiple Myeloma

Inclusion Criteria: 1. Age ≥ 18 years. 2. Life expectancy ≥ 3 months. 3. Eastern Cooperative Oncology Group (ECOG) performance status 0-2. 4. Adequate hepatic function. 5. Sufficient Absolute neutrophil count (ANC) within 14 days prior to randomization. 6. Sufficient Hemoglobin within 14 days prior to randomization (subjects may be receiving red blood cell (RBC) transfusions in accordance with institutional guidelines). 7. Sufficient platelet count 14 days prior to randomization. 8. Creatinine Clearance ≥ 30 mL/minute within 7 days prior to randomization. 9. Left Ventricular Ejection Fraction ≥ 40%. 10. Written informed consent in accordance with federal, local, and institutional guidelines. 11. Females of childbearing potential (FCBP) must agree to ongoing pregnancy testing and to practice contraception. 12. Male subjects must agree to practice contraception. 13. Patients must have histologically or cytologically confirmed symptomatic multiple myeloma (MM). Patients should not have previously been treated. 14. Prior kyphoplasty, vertebroplasty, local radiation therapy for symptomatic bone lesions (e.g., uncontrolled pain or high risk of pathologic fracture) are permitted. 15. Patients are allowed up to two cycles of high dose steroids if needed for symptomatic disease before study enrollment. Exclusion Criteria: 1. Patients who have had chemotherapy for Multiple Myeloma. Exception: local radiation therapy for symptomatic bone lesions (e.g., uncontrolled pain or high risk of pathologic fracture). 2. Patients currently receiving high dose systemic steroids for treatment of Multiple Myeloma in excess of 320mg total dose of dexamethasone or equivalent, patients who received an investigational agent within 5 half-lives of the agent. 3. Patients with non-measurable Multiple Myeloma or primary plasma cell leukemia. 4. Pregnant or lactating females. 5. Major surgery within 21 days prior to enrollment. 6. Acute active infection requiring treatment (systemic antibiotics, antivirals, or antifungals) within 14 days prior to enrollment. 7. Known human immunodeficiency virus (HIV) infection. 8. Known active hepatitis B or C infection. 9. Unstable angina or myocardial infarction within 4 months prior to enrollment. 10. Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment. 11. Uncontrolled, non-hematologic malignancy requiring active treatment. 12. Patients with known brain metastases (treated or not) will be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. 13. Significant neuropathy within 14 days prior to randomization. 14. Known history of allergy to Captisol, or to other agents in the study. 15. Contraindication to any of the required concomitant drugs or supportive treatments, including hypersensitivity to all anticoagulation and antiplatelet options, antiviral drugs, or intolerance to hydration due to preexisting pulmonary or cardiac impairment. 16. Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to enrollment. 17. Any other clinically significant medical disease or condition that, in the Investigator's opinion, may interfere with protocol adherence or a subject's ability to give informed consent.