LDE225 for Patients With PTCH1 or SMO Mutated Tumors

Inclusion Criteria: * Patient has confirmed diagnosis of a select solid tumor (except medulloblastoma, basal cell carcinoma and pancreatic adenocarcinoma) or hematological malignancy (except CML, ALL and AML). * Patient has pre-identified tumor with a PTCH1 or SMO mutation. * Patient has received at least one prior treatment for recurrent, metastatic and /or locally advanced disease and for whom no standard therapy options are anticipated to result in a durable remission. * Patient has progressive and measurable disease as per RECIST 1.1. or other appropriate hematological guidelines. * Patient has an Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1 Exclusion Criteria: * Patients has received prior treatment with LDE225. * Patients has neuromuscular disorders associated with elevated CK (i.e. inflammatory myopathies, muscular dystrophy, amyotrophic lateral sclerosis and spinal muscular atrophy) or are on concomitant treatment with drugs that are recognized to cause rhabdomyolysis * Patients has primary CNS tumor or CNS tumor involvement * Patient has received chemotherapy or anticancer therapy ≤ 4 weeks prior to starting study drug