Safety and Feasibility Study of Mesenchymal Trophic Factor (MTF) for Treatment of Osteoarthritis

Inclusion Criteria: * Age \>18 years and ability to understand the planned treatment. * Subjects 18 years of age or older with idiopathic or secondary osteoarthritis of the knee with grade 2, 3, or 4 radiographic severity, as defined by the modified Kellgren-Lawrence classification Exclusion Criteria: * Pregnant women or cognitively impaired adults. * Presence of large meniscal tears ("bucket handle" tears), as detected by clinical examination or by magnetic resonance imaging. * Inflammatory or post infectious arthritis. * More than 5 degrees of varus or valgus deformity. * Kellgren Lawrence grade 4 osteoarthritis in two compartments (the medial or lateral compartments of the tibiofemoral joint or the patellofemoral compartment) in persons over 60 years of age. * Intra-articular corticosteroid injection within the previous 3 months. * A major neurologic deficit. * Serious medical illness with a life expectancy of less than 1 year. * Prior admission for substance abuse * Body Mass Index (BMI) of 40 kg/m2 or greater * Patient receiving experimental medication or participating in another clinical study within 30 days of signing the informed consent * In the opinion of the investigator or the sponsor the patient is unsuitable for cellular therapy