Randomized Controlled Study of the Effectiveness of IV Fluid Infusion in Patients With Acute Ischemic Stroke (IVIS)

Inclusion Criteria: 1. Age from 18-80 years 2. NIHSS ≥ 1 3. Diagnosis of acute ischemic stroke within 72 hours from stroke onset 4. Enrollment into the study within 24 hours after hospital arrival 5. Urine specific gravity level \< 1.030 6. Patient consent Exclusion Criteria: 1. Patients receiving \> 40 ml/hr IV fluid infusion over 3 hours 2. Acute ischemic stroke caused cardiogenic embolism 3. Urine specific gravity ≥ 1.030 4. Large cerebral infarction area 1. Infarction \> 1/3 of middle cerebral artery area 2. Infarction \> 1/2 of cerebellar hemisphere 5. NHISS ≥ 18 6. Previous or current episode of atrial fibrillation 7. Previous or current episode congestive heart failure 8. Previous echocardiogram with ejection fraction \< 40% 9. Previous or current episode of dilated cardiomyopathy 10. Abnormal renal function GFR ≤ 60% or serum creatinine ≥ 2 11. Modified Rankin scale before acute ischemic stroke ≥ 2 12. Patients receiving intravenous thrombolysis 13. NPO with need for IV fluid 14. IV fluid infusion needed from any other causes 15. Patients with poor prognosis with life expectancy \< 90 days 16. Patients involved in other ongoing clinical studies