Revealing Increased Axonal Loss in Treated HIV Patients

N/ACompletedNCT02003989

Fondation Ophtalmologique Adolphe de Rothschild156 enrolled

Overview

HIV patients may suffer sooner from aging than average population, including brain aging. Our hypothesis is that if brain dysfunctions are explained by a quicker loss of neurons in HIV patients, this loss could be detected earlier by a thinning down of retinal nerve fiber layer (RNFL), compared to non HIV patients of the same age.

The investigators aim to compare the thickness of the RNFL and the thickness of the RCGs measured by spectral domain OCT between patients infected by HIV and patients of same age non infected by HIV.

Study Type

OBSERVATIONAL

Enrollment

156

Conditions

HIV Seropositivity

Interventions

ophthalmologic examination and MRIOTHER

thorough investigation of patients, not included in usual care.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * HIV infection known since at least 10 years * viral load undetectable under ARV treatment since at least 5 years, whatever the type of ARV * lymphocytes CD4 \> 350, whatever the CD4 nadir * signed informed consent Exclusion Criteria: * History of ocular pathology, eye surgery, or intraocular injection * Familial History of glaucoma * ametropia (\>3 dioptres on the sphere and \>1,5 dioptres on the cylinder) * known neurological pathology, active or former * History of ethambutol or synthetic antimalarial drug consumption * History of chemotherapy * Active and regular use of drugs * non-weaned chronic alcoholism * contra indication to MRI * diabetes * cognitive disorders (MoCA\<26) * non covered by health insurance * patient under legal protection * pregnant or breast-feeding woman * Non inclusion criteria for control patients: known HIV infection

Locations (1)

Fondation OPH A de Rothschild

Paris, Île-de-France Region, France

Outcomes

Primary Outcomes

thickness of the RNFL and the RCGs measured by spectral domain OCT, between the two groups of patients

Time frame: one day of examinations

Data from ClinicalTrials.gov

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