Neutrophil Extracellular Traps and Sickle Cell Disease

N/AUnknownNCT02004808

Tel-Aviv Sourasky Medical Center15 enrolled

Overview

NETs formation in vaso-occlusive events in sickle cell disease and the role of hydroxyurea treatment.The study hypothesis is that NETs formation by neutrophils has a role in the induction of vaso occlusive disease in blood vessels. It is possible that high leukocyte count in children with sickle cell anemia is a bad prognostic sign due to NETs formation supporting occlusion of peripheral and central blood vessels.Hydroxyurea treatment might prevent vaso occlusive syndrome not only by increasing HbF but also by decreasing neutrophil count and inhibiting NETs formation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sickle Cell Anemia

Eligibility

Sex: ALLMin age: 1 MonthMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * children who suffer from sickle cell disease and/or children with sickle cell disease treated with hydroxyurea Exclusion Criteria: * none

Outcomes

Primary Outcomes

measurements of neutrophil function

Time frame: at first admition (day 1)

Secondary Outcomes

measurements of neutrophil function

Time frame: at sickle cell crisis while hospitalized

Central Contacts

Ronit Elhasid, MD

CONTACT

972524266464 ronite@tasmc.health.gov.il

Data from ClinicalTrials.gov

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