Impact of Vitamin D on Endothelial Function and Blood Biomarkers Including CD28 Null Cells in CKD

Phase 3CompletedNCT02005718

St George's, University of London36 enrolled

Overview

Vitamin D deficiency is common in CKD and assciated with CV complications. Endothelial dysfucntion is common in CKD and is a harbinger of atherosclerosis. The study investigated the impact of Vitamin D on endothelial fucntion and blood biomarkers in CKD.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

CKd Patients With Stage 3 and 4

Interventions

CholecalciferolDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * CKD 3-4 Age 18-80 Exclusion Criteria: * Recent MI, CVA, malignancy active infection active inflammation High calcium already on Viatmin D therapy

Outcomes

Primary Outcomes

Flow mediated dilation

Time frame: 16 weeks

Secondary Outcomes

CD28 null cell frequency

Time frame: 16 weeks

Blood biomarkers of endothelial function and inflammation

Time frame: 16 weeks

Data from ClinicalTrials.gov

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