The purpose of this study is to evaluate the safety and effectiveness of Ublituximab in combination with TGR-1202, with or without ibrutinib or bendamustine, in patients with advanced hematologic malignancies
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
160
Ublituximab IV infusion TGR-1202 oral daily dose
Ublituximab IV infusion TGR-1202 oral daily dose Ibrutinib oral daily dose
Ublituximab IV infusion TGR-1202 oral daily dose Bendamustine IV infusion
TG Therapeutics Investigational Trial Site
Huntsville, Alabama, United States
TG Therapeutics Investigational Trial Site
Jonesboro, Arkansas, United States
TG Therapeutics Investigational Trial Site
Duarte, California, United States
TG Therapeutics Investigational Trial Site
Atlanta, Georgia, United States
Maximum Tolerated Dose acceptable for participants
To determine the incidence of adverse events, any potential abnormal laboratory results and any dose-limiting toxicities
Time frame: 28 days (1 cycle of therapy)
Overall Response Rate
To assess the overall response rate (ORR) in patients with hematologic malignancies treated with Ublituximab in combination with TGR-1202
Time frame: Up to 1 year
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TG Therapeutics Investigational Trial Site
Omaha, Nebraska, United States
MD Anderson Cancer Center
Houston, Texas, United States