Multiple-dose Pharmacokinetics of Ceftaroline During Continuous and Intermittent Renal Replacement Therapy in Patients Requiring Renal Replacement Therapy

Inclusion Criteria: * Age \>18 years, able to give written informed consent * Suspected or proven bacterial infection requiring parenteral antibiotic therapy. * Renal replacement therapy (continuous or intermittent) Exclusion Criteria: * Known hypersensitivity to ceftaroline or other cephalosporins, or severe hypersensitivity (anaphylactic reaction) to beta-lactam antibacterial agents. * An expected survival of less than two days. * Known pregnancy * Coadministration of valproic acid or probenecid, which cannot be discontinued for the duration of the study * Ceftaroline as monotherapy for resistent species or fungal infections. * Other reasons oposing the study participation on the discretion of the investigators