The Influence of High Impact Exercise on Musculoskeletal Health in Older Men

N/ACompletedNCT02007460

Loughborough University50 enrolled

Overview

Osteoporotic fractures are an extremely common and serious public health issue which contribute substantially to pain, impaired mobility and morbidity in the elderly. Declines in bone strength combined with an increase risk of falls (associated with decline in muscular function with age) are the main determinants of fracture risk. Exercise that is novel and involves impact loading has the potential to improve bone strength and neuromuscular function (strength, power and balance). It is thus imperative to evaluate potential benefits of exercise in older people. The musculoskeletal responses to exercise may also be influenced by vitamin D status. It is the purpose of this study to consider the influence of a one year unilateral (one limb) high impact exercise programme on musculoskeletal health, specifically bone structure, muscle strength and power in older caucasian men. It is also the purpose of this study to determine whether this differs according to vitamin D status. The findings will reveal whether exercise can improve bone health and/or neuromuscular function, and whether improvements are dependent upon vitamin D status.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Bone Strength Neuromuscular Function

Eligibility

Sex: MALEMin age: 65 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy community dwelling men of white european origin Exclusion Criteria: * BMI \>30 kg/m2 * History of strength training or recently ( previous 12 months) doing moderate physical activity (weight bearing, high impact) * Recent ( previous 12 months) or current medical or surgical problems likely to affect bone metabolism or provide contraindications to high impact exercise, balance or neuromuscular function * Any previous or existing lower back or limb problems that could be exacerbated by undertaking high impact exercise * Any history of diagnosed or symptomatic diseases likely to influence strength, power, bone or habitual activity (including osteomalacia or impaired liver/renal function and locomotor disease, hypertension) that influences bone or muscle or precludes exercise

Outcomes

Primary Outcomes

Change in femoral neck bone mineral density

Time frame: baseline, 12 months

Secondary Outcomes

Change in cortical bone mineral content

Time frame: baseline, 12 months

Change in trabecular bone mineral content

Time frame: baseline, 12 months

Change in ground reaction force during hopping

Time frame: baseline, 6 months, 12 months

Change in electromyography of quadriceps during hopping