Concentration of Ampicillin / Sulbactam and Amoxicillin / Clavulanic Acid in the Blood During Renal Replacement Therapy in Longterm Renal Replacement Therapy Patients

Inclusion Criteria: * Age \>18 years * Suspected or proven bacterial infection requiring parenteral antibiotic therapy. * Renal replacement therapy (HD) Exclusion Criteria: * Known hypersensitivity to ampicillin / sulbactam, amoxicillin / clavulanic acid or other beta-lactames, or severe hypersensitivity (anaphylactic reaction) to beta-lactam antibacterial agents. * An expected survival of less than two days. * Known pregnancy * Co-administration of one of the following drugs: probenecid which cannot be discontinued for the duration of the study * Ampicillin / sulbactam respectively amoxicillin / clavulanic acid as monotherapy for resistant species or fungal infections. * Other reasons opposing the study participation on the discretion of the investigators.