The primary aim of this study is to investigate the relationship between early plasma protein levels and hemodynamics in very preterm infants during postnatal transition. Secondary aims are the following: i) to evaluate maternal and neonatal factors affecting plasma protein level at birth; ii) to evaluate the relationship between plasma protein level and albumin level on the first day of life; iii) to evaluate the association between early hypoproteinemia and neonatal mortality and morbidity in very preterm infants.
Study Type
OBSERVATIONAL
Enrollment
125
* Patient inclusion at birth * Total plasma protein values measurement on cord blood sample at birth * Hemodynamic evaluation at 6 hours after birth with colour doppler echocardiography and organ blood flow colour doppler * Total plasma protein and albumin values measurement on plasma sample at 12 hours after birth * Blood pressure, heart rate, O2 saturation, capillary refill time, rSO2 \[regional (cerebral and somatic) tissue oxygenation by NIRS - near infrared spectroscopy\] will be monitored over 24 hours after birth.
Centre Hopsitalier Universitaire de La Réunion
Saint-Denis, La Réunion, France
Centre Hospitalier de La Réunion
Saint-Pierre, La Réunion, France
Evidence of clinical hemodynamic disturbances defined by arterial hypotension (non-invasive measure of MAP - mmHg - pathological for gestational age) or measured at organ colour doppler, echocardiography or NIRS
Time frame: about 6 hours after birth
plasma protein
plasma protein level on cord blood sample depending on maternal and neonatal variables
Time frame: at 1 second after birth (cord blood sample)
Albumin level
Time frame: At 12 hours after birth
Mortality rate
Time frame: patients will be followed for the duration of hospital stay, that is an average of 8 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.