Bronchoreversibility and Radiologic Morphology of Emphysema

N/AUnknownNCT02008162

University of Rome Tor Vergata60 enrolled

Overview

To assess response to bronchodilation with tiotropium plus salbutamol in patients with severe emphysema and analyze relationships between bronchoreversibility response and semiquantitative computed-tomography based emphysema severity measures.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Emphysema COPD

Interventions

BronchodilatorsDRUG

Administration of both albuterol and tiotropium bromide after a 48h period of washout from all bronchodilators, followed by spirometry and plethysmography

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Radiologic evidence of severe heterogeneous emphysema * GOLD COPD class III-IV * No other significant pulmonary comorbidity * Quit smoking since at least 4 months

Locations (1)

Fondazione Policlinico Tor Vergata

Rome, Italy

RECRUITING

Outcomes

Primary Outcomes

post-bronchodilator FEV1 change

Assessed by spirometry carried out before and after administration of bronchodilators

Time frame: 1 h

post-bronchodilator change in FVC

Assessed by spirometry carried out before and after administration of bronchodilators

Time frame: 1h

Data from ClinicalTrials.gov

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