Multiple sclerosis (MS) is a chronic progressive neurological disease, the leading cause of disability after injury accidents in young adults. Among the many symptoms, fatigue is very common with a significant impact on quality of life. Also, the disability caused by multiple sclerosis can alter food intake and can cause nutritional deficiencies. Nutrients such as proteins, minerals (iron, calcium, magnesium), some vitamins (B12, 25 OHD) are often deficient in this population with consequences in physical performance such as endurance and muscle strength. We propose to study the link between fatigue and shortcomings encountered in a defined population of MS patients.
Study Type
OBSERVATIONAL
Enrollment
360
A blood sample will be taken from each patient and the following parameters will be assessed : magnesium, albumin, Vitamin B12, Vitamin D, Calcium, Iron.
16 Taste Strips impregnated with 4 flavors (sweet, sour, salty, bitter, each flavor present at 4 different concentrations), are offered to the patient one after the other in a so-called pseudorandomized sequence. The task of the patient is to choose one of the following answers: sweet / sour / salty / bitter / no taste. Each correct answer is granted one point. In addition to the impregnated strips, two tasteless strips can be integrated in the examination at any point of time (no point)
Evaluation of the following parameters by validated questionnaires (name of the questionnaire in bracket): * Fatigue (EMIF-SEP) * Dysphagia (DYMUS) * Food intake (semi-structured questionnaire) * Depression (BDI-II) * Daily energy expenditure (NAP) * Visual analog scale to study quality of sleep
Centre Hospitalier Universitaire de Caen
Caen, Basse-Normandie, France
Centre Hospitalier d'Arras
Arras, Hauts-de-France, France
Centre Hospitalier de Boulogne, Hôpital Duchenne
Boulogne-sur-Mer, Hauts-de-France, France
Centre Hospitalier de Calais
Calais, Hauts-de-France, France
Centre Hospitalier de Douai
Douai, Hauts-de-France, France
Groupement des Hôpitaux de l'Institut Catholique de Lille
Lille, Hauts-de-France, France
Centre Hospitalier Régional Universitaire de Lille
Lille, Hauts-de-France, France
Centre Hospitalier de Sambre-Avenois
Maubeuge, Hauts-de-France, France
Centre Hélène Borel
Raimbeaucourt, Hauts-de-France, France
Centre Hospitalier Dron de Tourcoing
Tourcoing, Hauts-de-France, France
...and 2 more locations
Correlation between the score of fatigue EMIF-SEP and the dosage of nutrients in blood (vitamins, minerals, proteins) adjusted by the EDSS status
The objective is to construct and validate a regression model between the scale of fatigue and biological variables
Time frame: Baseline
Presence or absence of sociodemographic variables
Time frame: Baseline
Presence or absence of clinical manifestations
Time frame: Baseline
Level of physical activity and daily energy expenditure
Time frame: Baseline
Assessment of dysphagia according to the score of the Dymus Test
Time frame: Baseline
Score of the taste sensibility test
Time frame: Baseline
Score of the Beck depression inventory test
This test is a 21-question multiple-choice self-report inventory for measuring the severity of depression
Time frame: Baseline
Score of the visual analog scale for the evaluation of sleep quality
Time frame: Baseline
Score of the Nutrition and Eating Habits Questionnaire
Time frame: Baseline
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