This trial is conducted in Asia. The aim of this trial is to investigate the efficacy and safety of liraglutide compared to sitagliptin, both as add-on to metformin in Chinese subjects with type 2 diabetes inadequately controlled on metformin monotherapy. Eligible subjects will continue their metformin background treatment during the trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
368
Administered subcutaneously (s.c., under the skin) once daily as add-on to the subject's stable pre-trial metformin dose.
Administered orally once daily as add-on to the subject's stable pre-trial metformin dose.
Novo Nordisk Investigational Site
Change From Baseline in Glycosylated Haemoglobin (HbA1c)
Mean change from baseline in glycosylated haemoglobin A1c (HbA1c) at Week 26.
Time frame: Week 0, week 26
Change From Baseline in Fasting Plasma Glucose
Mean change from baseline in fasting plasma glucose (FPG) at Week 26.
Time frame: Week 0, week 26
Change From Baseline in 7-point Self-measured Plasma Glucose Profile
Mean change from baseline in mean of 7-point self-measured plasma glucose at week 26. The 7-point self-measured plasma glucose levels were measured before and after (120 minutes after the start of the meal) the three main meals (breakfast, lunch and dinner), and at bed time.
Time frame: Week 0, week 26
Subjects Who Achieve (Yes/no) HbA1c Below 7.0 % (American Diabetes Association Target)
Calculated as the percentage of subjects achieving treatment target of HbA1c \< 7.0% at Week 26
Time frame: After 26 weeks of treatment
Subjects Who Achieve (Yes/no) HbA1c Below or Equal to 6.5 % (American Association of Clinical Endocrinologists Target)
Calculated as the percentage of subjects achieving treatment target of HbA1c \<= 6.5% at Week 26
Time frame: After 26 weeks of treatment
Number of Confirmed Hypoglycaemic Episodes
confirmed hypoglycaemic episode defined as severe (unable to treat her/himself) or biochemically confirmed by a plasma glucose \< 3.1 mmol/L
Time frame: Weeks 0-26
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Beijing, Beijing Municipality, China
Novo Nordisk Investigational Site
Beijing, Beijing Municipality, China
Novo Nordisk Investigational Site
Beijing, Beijing Municipality, China
Novo Nordisk Investigational Site
Chongqing, Chongqing Municipality, China
Novo Nordisk Investigational Site
Cangzhou, Hebei, China
Novo Nordisk Investigational Site
Hengshui, Hebei, China
Novo Nordisk Investigational Site
Shijiazhuang, Hebei, China
Novo Nordisk Investigational Site
Shijiazhuang, Hebei, China
Novo Nordisk Investigational Site
Nanjing, Jiangsu, China
Novo Nordisk Investigational Site
Nanjing, Jiangsu, China
...and 15 more locations