A Comparison of Propofol Based Total Intravenous Anesthesia and Sevoflurane Based Balanced Anesthesia on Renal Protection During Lung Transplantation Under Extracorporeal Membrane Oxygenation - A Prospective, Randomized Trial

Phase 4CompletedNCT02009280

Yonsei University60 enrolled

Overview

The aim of this study is to investigate whether propofol based total intravenous anesthesia reduces incidence of acute kidney injury following the lung transplantation under extracorporeal membrane oxygenation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Patients Undergoing Lung Transplantation Under Extracorporeal Membrane Oxygenation

Interventions

Administration of anesthesia: PropofolDRUG

Maintenance of anesthesia with the propofol

Administration of anesthesia: SevofluraneDRUG

Maintenance of anesthesia with the sevoflurane

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Sixty adults undergoing lung transplantation under extracorporeal membrane oxygenation Exclusion Criteria: * Patient having propofol allergy, BMI \> 30 kg/m2

Locations (1)

Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University Health System

Seoul, South Korea

Outcomes

Primary Outcomes

Comparison of the incidence of acute kidney injury between the lung transplantation recipients under propofol based anesthesia and inhalation based anesthesia

Developement of the acute kidney injury is determined by Plasma neutrophil gelatinase-associated lipocalin (NGAL), Cystatin C, and Creatinine

Time frame: Postoperative 48 hours

Data from ClinicalTrials.gov

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