The purpose of this study is to compare abdominal weight gain and fat distribution to changes in brain morphology in people taking antipsychotic medications.
Abdominal weight gain is a significant side effect of antipsychotic medications. It has even been suggested to be part of the pathology of severe mental illnesses. Studies have shown that in persons with bipolar disorder, increased body mass index (BMI) is associated with irregular changes in the brain. This association has not been tested in persons with psychosis. In this study, we will be measuring abdominal fat distribution as measured by MRI to see if this is associated with abnormal brain morphology.
Study Type
OBSERVATIONAL
Enrollment
40
BC Mental Health & Addictions Research Institute
Vancouver, British Columbia, Canada
RECRUITINGAbdominal distribution of visceral fat versus subcutaneous fat
Change over time in amounts of visceral and subcutaneous fat as measured by automated segmentation of a magnetic resonance image (MRI)
Time frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge
Changes in total brain volume
Change over time in total brain volume as measured by automated segmentation of a magnetic resonance image (MRI).
Time frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge
Changes in grey matter volume in the brain
Change over time in amounts of brain grey matter as measured by automated segmentation of a magnetic resonance image (MRI).
Time frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge
Changes in white matter volume in the brain
Change over time in amounts of brain white matter as measured by automated segmentation of a magnetic resonance image (MRI).
Time frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge
Changes in the volume of brain structures
Change over time in the volume of brain structures as measured by automated segmentation of a magnetic resonance image (MRI).
Time frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge
Comparing changes in abdominal fat distribution/accumulation to psychosis symptom severity
To determine if an association exists between abdominal fat accumulation/distribution and psychosis symptom severity, as measured by the amounts of visceral and subcutaneous fat by automated segmentation of a magnetic resonance image (MRI) and standardized symptom rating scales, cognitive tests, and other neuropsychological examinations, respectively.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge