aggressive periodontitis is an inflammatory disease which damage the teeth supporting structures mostly in young patients. and has genetic basis. a specific bacteria: Aggregatibacter actinomycetemcomitans (Aa) is associated with this disease, and found to damage leukocytes by using a specific leukotoxin. in the research the investigators are aiming to find molecular and immunological basis to aggressive periodontitis.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
75
6 ml blood extraction from each patients in all 3 arms of the study
Hadassah Medical Organization, Jerusalem, Israel
Jerusalem, Israel
flow cytometry
the investigators use flow cytometry technique in order to determine the influence of gingival bacteria on the leukocytes, after culturing the two together.
Time frame: 12 hours after blood extraction
microscopy observation
the investigators use microscopy in order to determine the influence of gingival bacteria on the leukocytes, after culturing the two together
Time frame: 12 hours after blood extraction
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