Achalasia and Dysplasia

N/AUnknownNCT02010983

KU Leuven80 enrolled

Overview

Patient with achalasia have a 10-50 fold increased risk to develop esophageal squamous cell carcinoma (ESCC). Early diagnosis of ESCC is essential, and detection of an earlier dysplastic stage is preferred. Endoscopic detection is however difficult and often delayed. Chromoendoscopy with Lugol dye increases detection rates dysplasia and ESCC to 91-100%. The aim of this study was therefore to evaluate a screening program using chromoendoscopy with Lugol to detect dysplasia in patients with idiopathic achalasia. A second objective is to study the relationship between foodstasis and the development op dysplasia

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Dysplasia in Longstanding Achalasia Relation Between Food Stasis and Dysplasia

Interventions

chromoendoscopyOTHER

chromoendoscopy (lugol stain and virtual chromoendoscopy)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * longstanding achalasia (\> 15y) * \> 18y old * informed consent Exclusion Criteria: * allergy to iodine * esophageal carcinoma

Locations (1)

UZleuven

Leuven, Belgium

RECRUITING

Outcomes

Primary Outcomes

incidence of dysplasia in patients with longstanding achalasia

Time frame: 1 year

Secondary Outcomes

additive value of chromoendoscopy in comparison with lugol stain

Time frame: 1 year

relationship between food stasis and dysplasia

* relationship between elevated LES pressure and dysplasia * relationship between stasis on EndoFLIP and dysplasia * relationship between stasis on timed barium esophagogram and dysplasia

Time frame: 1 year

Central Contacts

an moonen, MD

CONTACT

an.moonen@med.kuleuven.be

Data from ClinicalTrials.gov

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