Effect of Milk Ingredients on Glucose Regulation and Inflammation

Inclusion Criteria: * BMI 28-35 kg/m2 * Waist circumference \>102 cm * Healthy as assessed by the NIZO lifestyle and health questionnaire and results of the pre-study safety laboratory tests. * Regular and normal Dutch eating habits as assessed by the NIZO lifestyle and health questionnaire (3 main meals per day) * Habitual consumption of dairy products as assessed by dietary questionnaire * Voluntary participation * Having given written informed consent * Willing to comply with study procedures * Access to internet * Willing to accept use of all encoded data, including publication, and the confidential use and storage of all data for at least 15 years. * Willing to accept disclosure of the financial benefit of participation in the study to the authorities concerned Exclusion Criteria: * Participation in any clinical trial including blood sampling and/or administration of substances up to 90 days before Day 01 of this study * Participation in any non-invasive clinical trial up to 30 days before Day 01 of this study, including no blood sampling and/or oral, intravenous or inhalatory administration of substances * Having a history of medical or surgical events that may significantly affect the study outcome, including: Inflammatory bowel disease, ulcers, gastrointestinal or rectal bleeding; major gastrointestinal tract surgery such as gastrectomy, gastroenterostomy, or bowel resection; known or suspected gastrointestinal strictures * Medical drug use; antibiotics, laxatives, glucose lowering drugs, insulin; all medication with an inflammation inhibiting effect (e.g. NSAIDS, corticosteroids) and/or an effect on blood coagulation (e.g. coumarins, inhibitors of thrombin or factor Xa, acetylsalicylic acid, antidepressants from the group of serotonin reabsorption inhibitors, tranexamin acid) * Mental status that is incompatible with the proper conduct of the study * A self-reported reported food allergy or sensitivity (wheat, milk, lactose, eggs, nuts, etc) * Alcohol consumption \> 28 units/week and 4/day * Exercise \> 3 hours/week * Smoking \>20 cigarettes/day * Reported unexplained weight loss or weight gain of \> 3 kg in the month prior to pre-study screening * Reported slimming or medically prescribed diet * Reported vegan or macrobiotic life-style * Recent blood donation (\<1 month prior to Day 01 of the study) * Not willing or afraid to give up blood donation during the study * Personnel of NIZO food research or Wageningen University, department of Human Nutrition, their partner and their first and second degree relatives * Not having a general practitioner * Not willing to accept information-transfer concerning participation in the study, or information regarding his health, like laboratory results, findings at anamnesis or physical examination and eventual adverse events to and from his general practitioner