Prospective Observational Study of Disease Progression in Chronic Hepatitis C

N/AActive Not RecruitingNCT02011932

Beijing YouAn Hospital133 enrolled

Overview

The purpose of this study is to determine the progression of chronic hepatitis C patients infected by paid plasma donation,and explore the possible pathogenic mechanisms of disease progression in chronic hepatitis C.

Study Type

OBSERVATIONAL

Enrollment

133

Conditions

Hepatitis C, Chronic Disease Progression Liver Cirrhosis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * All these patients had a definite history of regular plasma donations with repeated blood cell re-transfusions. * The Hepatitis C Virus antibody was positive. * All patients did not receive interferon therapy before being recruited. Exclusion Criteria: * Patients with evidences for other forms of liver diseases. * The coinfection with hepatitis B virus or other virus.

Outcomes

Primary Outcomes

Fibrosis progression rate

Time frame: 20 years

The incidence of cirrhosis

Time frame: 20 years

Risk factors for the occurrence of cirrhosis

Time frame: 20 years

Secondary Outcomes

The incidence of hepatocellular carcinoma

Time frame: 20 years

Number of participants with chronic hepatitis C-related complications

Time frame: 20 years

Data from ClinicalTrials.gov

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