Effects of Postoperative Pain Management on Immune Function After Laparoscopic Resection of Colorectal Cancer

N/ACompletedNCT02012244

Severance Hospital60 enrolled

Overview

The purpose of this study is to compare postoperative immune function (e.g. NK cell activity) of fentanyl-based analgesic regimen versus local anesthetic wound infiltration-based anlagesic regimen after laparoscopic colorectal surgery

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Colorectal Surgery

Interventions

fentanyl-based analgesiaDRUG

fentanyl based patient-controlled analgesia + additional pethidine for postoperative 48 hour

local anesthetic wound infiltration-based anlagesiaDRUG

continuous wound inflitration with ropivacaine + tramadol patient-controlled analgesia + additional ketorolac or propacetamol for postoperative 48 hour

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA class I-III * 20-80 years old * elective laparoscopic colorectal surgery for cancer Exclusion Criteria: * drug allergy * significant renal or hepatic impairment * sign of infection

Locations (1)

Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine

Sedoul, South Korea

Outcomes

Primary Outcomes

NK cell activity

NK cell activity : preoperation, POD 1, POD 2

Time frame: 48 hours

IL-2

IL-2 level : preoperation, POD 1, POD 2

Time frame: 48 hours

Secondary Outcomes

Complication and recurrence

Postoperative complication, recurrence

Time frame: 1 year

Data from ClinicalTrials.gov

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