The purpose of this study is to determine whether combination of ketamine plus electroconvulsive therapy improves depressive symptoms decreasing cognitive side effects.
This study will compare the clinical response to brief pulse ECT with infusion of ketamine 0.5 mg/kg versus brief pulse electroconvulsive therapy with infusion of placebo (saline) in major depression. We also will compare levels of cognitive impairment among these groups, compare levels of quality of life among these groups, compare levels of BDNF among these groups. We also will study if levels of 25-hydroxyvitamin D are associated with cognitive impairment in subjects undergoing ECT.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Brief pulse ECT with 0.05 mg/kg ketamine infusion in each session
Federal University of Rio Grande do Sul / Hospital de Clínicas de Porto Alegre (HCPA)
Porto Alegre, Rio Grande do Sul, Brazil
Hamilton Depression Scale (HAM-D) 17 change
Time frame: Baseline, week 1, week 2, week 3, week 4, and at the end of hospital stay, an expected average of 5 weeks
Mini Mental Status Exam change
Time frame: Baseline and at the end of hospital stay, an expected average of 5 weeks
Autobiographical Memory Test change
Time frame: Baseline and at the end of hospital stay, an expected average of 5 weeks
Rey Auditory Verbal Learning Test change
Time frame: Baseline and at the end of hospital stay, an expected average of 5 weeks
WAIS Digit Span change
Time frame: Baseline and at the end of hospital stay, an expected average of 5 weeks
FAS verbal fluency change
Time frame: Baseline and at the end of hospital stay, an expected average of 5 weeks
Stroop Test change
Time frame: Baseline and at the end of hospital stay, an expected average of 5 weeks
Trial Making Test change
Time frame: Baseline and at the end of hospital stay, an expected average of 5 weeks
WAIS Vocabulary
Time frame: Baseline
Montgomery and Asberg Depression Rating Scale change
Time frame: Baseline, week 1, week 2, week 3, week 4, and at the end of hospital stay, an expected average of 5 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Brief Psychiatry Rating Scale change
Time frame: Baseline, week 1, week 2, week 3, week 4, and at the end of hospital stay, an expected average of 5 weeks
Clinical Global Impression-Severity change
Time frame: Baseline, week 1, week 2, week 3, week 4, and at the end of hospital stay, an expected average of 5 weeks