The Effect of a Multi-component Weight Management Program on Appetite, Food Preference and Body Weight

N/ACompletedNCT02012426

University of Leeds96 enrolled

Overview

The aim of the current study is to demonstrate that a commercial weight management diet (i.e. low energy density) influences satiation, hunger and satiety and leads to lower energy intake during ad-libitum meals and over a full day. We further seek to demonstrate the sustainability of this effect following 12- week weight loss on the weight management program. * We hypothesise that formulated (low energy) meals will lead to decreased hunger, greater fullness and reduced desire to eat compared to standard meals. * We hypothesise that the commercial weight management program will lead to greater weight loss compared to control program. * We hypothesise that formulated meals (high consumer acceptance) will improve hedonic control over eating (lower wanting for high fat food) * We hypothesise that the commercial weight management program will improve hedonic control over eating (reduced experience food cravings)

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Overweight Obesity Sedentary Lifestlye

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI of 28 - 45 kg/m2 * Reporting an interest in weight loss, not actively participating in a commercial weight loss program, * Not increased physical activity levels in the past 2-4 weeks * Able to eat most everyday foods and fruits and vegetables * Written informed consent to be given Exclusion Criteria: * Significant health problems that could cause confounding effects between intervention and control. * Taking any medication or supplements known to affect appetite or weight within the past month and/or during the study * Pregnant, planning to become pregnant or breastfeeding * History of anaphylaxis to food * Known food allergies or food intolerance * Smokers and those who have recently ceased smoking * Participants receiving systemic or local treatment likely to interfere with evaluation of the study parameters * Those who have previously taken part in a commercial weight loss program in the last 6 months? . * Participants who work in appetite or feeding related areas * Participants unable to consume foods used in the study * Participants who have had bariatric surgery * Participants with a history of eating disorder * Presence of untreated hypothyroidism * Inability to fully comply with intervention or study procedures * Insufficient English language skills to complete study questionnaires

Outcomes

Primary Outcomes

Test Meal Energy Intake

Measured reductions in ad-libitum energy intake following consumption of formulated test meal in comparison to control.

Time frame: Week 0 and week 12

24h Energy Intake

Measured reduction in total within-day energy intake following consumption of formulated meals in comparison to control

Time frame: Week 0 and week 12

Appetite sensations

Measured reduction in hunger and increase in satiety quotient following consumption of formulated test meal in comparison to equi-energetic control

Time frame: Week 0 and week 14

Food preference

Measured changes in food preference and liking and wanting profiles for food (HF\<LF) following consumption of formulated test meal in comparison to equi-energetic control

Time frame: Week 0 and week 14

Secondary Outcomes

Body Weight

Measured change in weight and energy balance parameters over a 12 week period following participation in commercial weight management program compared to control group.

Time frame: Weekly from week 0 to week 12