Fruit and vegetable rich diets are associated with a reduced risk of cardiovascular disease (CVD). The protective effect may be ascribed to compounds contained within these foods, called flavonoids. Flavanols (epicatechin and procyanidins) are a particular group of flavonoids and are found mostly in apples, berry fruits, dark chocolate, tea and red wine. There is evidence to suggest that ingestion of flavanol rich foods and beverages beneficially alter 'markers' of CVD risk (e.g. blood pressure). The aim of this study is to determine the acute and chronic effects of apple derived flavanols on some risk markers for CVD.
This study is a single arm randomized, 4-phase crossover design.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
42
70 mg epicatechin and 65 mg procyanidins once daily for 28 days
140 mg epicatechin and 130 mg procyanidins once daily for 28 days
No epicatechin and 130 mg procyanidins once daily for 28 days
Placebo control once daily for 28 days
Institute of Food Research
Norwich, Norfolk, United Kingdom
Changes in systolic blood pressure from baseline
Time frame: Baseline, 2 hours and 4 weeks
Changes in plasma lipid profile from baseline
Time frame: Baseline and 4 weeks
Change in plasma endothelin-1 from baseline
Time frame: Baseline and 4 weeks
Changes in plasma nitric oxide metabolites from baseline
Time frame: Baseline, 2 hours and 4 weeks
Changes in blood glucose from baseline
Time frame: Baseline and 4 weeks
Changes in pulse wave velocity from baseline
Time frame: Baseline, 2 hours and 4 weeks
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