PWV for Cardiovascular Complication After Cardiac Surgery

N/ACompletedNCT02014012

Seoul National University Hospital60 enrolled

Overview

Arterial stiffness has been suggested as an independent risk factor for the development of coronary artery disease and stroke. Pulse wave velocity (PWV) is an noninvasive established index to quantify arterial stiffness. Therefore, we try to investigate the correlation between PWV values and cardiovascular complications like stroke, acute renal failure, or perioperative myocardial infarction after cardiac surgery.

Study Type

OBSERVATIONAL

Enrollment

Conditions

C.Surgical Procedure; Cardiac

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cardiac surgery patients who sign the informed consent Exclusion Criteria: * Chronic renal failure (Cr\>1.5mg/dL), Dialysis patients * Previous stroke * Left ventricular dysfunction (EF \<50%) * ASO with claudication * \< 40 years

Locations (1)

SMG-SNU Boramae Medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

Postoperative cardiovascular complication and parameters

Stroke, Delirium, Newly developed atrial fibrillation, ARF, Peak CK-MB and troponin I levels measured at 12 and 24 hours after surgery, Peak estimated GFR and corresponding creatinine

Time frame: within the first 7 days after surgery

Secondary Outcomes

E/e' and e' measured by transthoracic echocardiography with color-coded tissue dopper imaging in patients undergoing non-valvular cardiac surgery

peak early transmitral filling velocity during early diastole (E), mean early velocity at the septal mitral annulus (e')

Time frame: baseline and within the first 14 days after surgery

Data from ClinicalTrials.gov

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