Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents

Inclusion Criteria: A. Disease inclusions 1. Hematologic malignancy: * Acute lymphoblastic leukemia including induction failure, CR1 (Ph+, t(4:11), hypodiploid and other very high risk features), ≥ CR2, infant ALL with MLL or other unfavorable features * Acute myeloid leukemia excluding CR1 with t(8:21), inv(16), t(15:17), and Down syndrome * Myelodysplastic syndrome: RCC with -7 or RCC in need of transfusion * Chronic myeloid leukemia in AP * Juvenile myelomonocytic leukemia * Malignant lymphoma, NHL or HD, after failed autologous HSCT * Other 2. Non-hematologic malignancy * Relapsed or refractory solid tumors including neuroblastoma, rhabdomyosarcoma and so on 3. Non-malignant hematologic disease * Acquired severe and very severe aplastic anemia * Fanconi anemia * Paroxysmal nocturnal hemoglobinuria * Congenital dyserythropoietic anemia * Others 4. Inherited or metabolic disease * Hemophagocytic lymphohistiocytosis * Malignant osteopetrosis * Storage diseases * Others B. Recipient inclusions 1\. Age \< 21 years 2. No HLA-identical stem cell donor available 3. Lansky-Play performance score \>60 4. No active infection at the time of transplantation Exclusion Criteria: 1. HIV-infection 2. Presence of active and serious infection 3. Cardiac ejection fraction \<35% on echocardiography 4. Severe pulmonary dysfunction (DLCO \<30%) 5. Liver function abnormalities with bilirubin \>4mg/dL and elevation of transaminases \> 400U/L 6. Concurrent severe or uncontrolled medical disease 7. Patients who are pregnant 8. Patients unwilling or unable to comply with the protocol or unable to give informed consent