500 patients with normal renal function will be prospectively studied and incidence, spectrum and natural history of AKI (Acute Kidney Injury) will be observed in them and in 200 patients with abnormal renal function fulfilling AKI (Acute Kidney Injury) criteria will be prospectively studied for 1 year. Also biomarkers will be studied and validated as early predictors of AKI (Acute Kidney Injury).
Study Type
OBSERVATIONAL
Enrollment
450
Institute of Liver & Biliary Sciences
New Delhi, National Capital Territory of Delhi, India
The incidence , spectrum and natural history of Acute Kidney Injury in patients with cirrhosis
Incidence is defined as No. of AKI (Acute Kidney Injury) patients during the follow up period of 1 year. Spectrum is defined as Grading of AKIN (Acute Kidney Injury Network) 1,2,3 in different child status (Child A,Child B and Child C) at the end . Natural History is defined as Occurrence of AKI (Acute Kidney Injury) and its recovery during the follow up period of 1 year.
Time frame: 1 Year
To study predictive value of Cystatin C in comparison to serum creatinine as early predictor of development and outcome of AKI in a cohort of Cirrhotics.
Time frame: 1 Years
To study predictive value of Cystatin C to determine progression or resolution of Acute Kidney Injury
Time frame: 1 Years
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