Biomarker Discovery in Parkinson's Disease

Inclusion Criteria: For PD cases: Inclusion Criteria: * Men and women with the clinical diagnosis of idiopathic PD * Willing and able to give informed consent * Willing and able to comply with scheduled visits, required study procedures and laboratory tests Exclusion Criteria: PD Subjects with any of the following may not be enrolled: 1. Presence of atypical or secondary parkinsonism 2. Inability to provide a blood and/or urine sample 3. History of renal failure and/or on dialysis 4. Currently taking a medication in the following categories: dopamine blockers, neuroleptics, and/or dopamine blocking agents. 5. Any medical, psychiatric or other condition which, in the opinion of the investigator, would preclude participation Healthy Controls: All of the following criteria must be met for a Healthy Control to be enrolled in the study: 1. Healthy controls with no diagnosis of PD and any of the exclusion criteria 2. Willing and able to give informed consent 3. Willing and able to comply with scheduled visits, required study procedures and laboratory tests Healthy Controls with any of the following may not be enrolled: 1. No clinically significant or unstable medical or psychiatric condition that would interfere with the conduct of the study 2. Diagnosis of PD or presence of signs of a neurodegenerative disorder, e.g. essential tremor 3. First degree relative with PD/parkinsonism 4. Inability to provide a blood and/or urine sample 5. History of renal failure and/or on dialysis 6. Any medical, psychiatric or other condition which, in the opinion of the investigator, would preclude participation