Prognostic Value of Tumor Hypoxia, as Measured by 18F-FMISO Breath Hold PET/CT, in Non-Small-Cell-Lung Cancer (NSCLC) Patients

Inclusion Criteria: * Pathologic confirmation of NSCLC at MSKCC * No prior treatment for this diagnosis of NSCLC * Patient to be treated with neoadjuvant chemotherapy (35 patients total) or patient to be treated with definitive RT,sequential chemo-RT, or concurrent chemo-RT (minimum dose of 50 Gy in 25 fractions) (25 patients total) * Tumor must measure ≥ 2cm on CT * Age ≥ 18 years * Ability to hold the breath for 10 seconds. * Karnofsky performance status ≥ 70% * Women of childbearing age must have a negative blood pregnancy test Exclusion Criteria: * Women who are pregnant or breast-feeding * Severe diabetes (fasting Blood Glucose \> 200 mg/dl)