A Dose-Ranging Study of the Effect of Glycopyrrolate in Subjects With Axillary Hyperhidrosis

Inclusion Criteria: * Male or female, 18 years of age or older. * Primary, axillary hyperhidrosis of at least 6 months duration. * A Hyperhidrosis Disease Severity Score (HDSS) of 3or 4. * A gravimetric measurement of sweat production of at least 50 mg over 5 minutes in each axilla (total of 100 mg) while at rest at room temperature. * Male or non-pregnant, non-lactating females. Exclusion Criteria: * Prior surgical procedure for hyperhidrosis. * Any prior treatment with an axillary anti-hyperhidrosis medical device (approved or investigational) * Prior treatment with botulinum toxin for axillary hyperhidrosis within 1 year. * Treatment with cholinergic, serotonergic antagonists, and dopamine partial agonists thought to relieve antidepressant-induced hyperhidrosis. Treatment with psychotherapeutic medications for less than 4 months prior to study enrollment. - Treatment with topical or systemic anticholinergics, adrenergic agonists (clonidine), or beta-blockers within 4 weeks prior to enrollment. * Prior axillary treatment with axillary iontophoresis within 4 weeks. * Axillary use of nonprescription or prescription antiperspirants within 2 weeks of study enrollment. * Known history of a condition that may cause secondary hyperhidrosis. * Known history of Sjögren's syndrome or Sicca syndrome. * Abnormal findings on screening ECG deemed clinically significant by the Investigator.