This trial is conducted in Europe. The aim of the trial is to investigate the pharmacokinetics (the exposure of the trial drug in the body), safety and tolerability of oral semaglutide (NNC0113-0217) in subjects with mild, moderate and severe degrees of hepatic impairment compared to subjects with normal hepatic function.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
56
Once daily oral administration of semaglutide formulated with SNAC. Dose escalation, with 5 days on 5 mg followed by 5 days on 10 mg
Novo Nordisk Investigational Site
Prague, Czechia
Novo Nordisk Investigational Site
Prague, Czechia
Novo Nordisk Investigational Site
Bialystok, Poland
Novo Nordisk Investigational Site
Warsaw, Poland
Area under the semaglutide plasma concentration curve
Time frame: From time 0 to 24 hours after the 10th dosing
Maximum observed semaglutide plasma concentration
Time frame: 0 to 24 hours after the 10th dosing
Area under the SNAC (Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate /salcaprozate sodium) plasma concentration time curve
Time frame: From time 0 to 24 hours after the 10th dosing
Maximum observed SNAC plasma concentration
Time frame: 0 to 24 hours after the 10th dosing
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Novo Nordisk Investigational Site
Wołomin, Poland
Novo Nordisk Investigational Site
Bratislava, Slovakia