The aim of this study is 1. to describe levofloxacin pharmacokinetics in ICU patients suffering from pneumonia with taking into account physio-pathological parameters. 2. to verify clinical and bacteriological efficiency and to know if the peak/Minimum Inhibitory Concentration (MIC) ratio \> 5 and Area Under Curve (AUC) /Minimum Inhibitory Concentration(MIC) ratio \> 125. No therapeutic drug monitoring will be performed in this study.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
52
8 blood sampling by patients between the 48th and 60th
University Hospital Toulouse
Toulouse, France
Levofloxacin dosage regimen, time of administration and time of blood sampling, levofloxacin serum concentrations.
Time frame: Levofloxacin concentration assessment at 8 different time points during 12h
Efficiency (clinical,bacteriological, pharmacodynamic)
age, weight, height, sex, SAPS II, blood urea nitrogen (BUN), creatinine, mechanical ventilation, leukocytes, haemoglobin, procalcitonin, creatinine clearance, proteins, MIC of the strain.
Time frame: 12 hours
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