High Fructose Corn Syrup

N/ACompletedNCT02018237

Washington University School of Medicine47 enrolled

Overview

The purpose of this research study is to learn more about how high fructose corn syrup, a sugar used to sweeten drinks and foods, affects metabolism in obese persons with and without nonalcoholic fatty liver disease. Eligible participants will be studied before and after eating a diet high in high fructose corn syrup or a standard diet (low in high fructose corn syrup) for four weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Nonalcoholic Fatty Liver Disease Obesity

Interventions

High fructose corn syrup dietBEHAVIORAL

Subjects will consume a high fructose corn syrup diet for 4 weeks. The food will be prepared by the bio-nutrition kitchen, and meals will be picked up every 3-4 days.

Standard diet (low in high fructose corn syrup)BEHAVIORAL

Subjects will consume a standard diet (low in high fructose corn syrup) for 4 weeks. The food will be prepared by the bio-nutrition kitchen, and meals will be picked up every 3-4 days.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * IHTG \>6.5% or \<5% * BMI 30.0-45.0 kg/m² * Sedentary * Consume \<10% calories from high fructose corn syrup * Weight stable for previous 3 months Exclusion Criteria: * IHTG 5.1-7.9% * Children * Adults over 65 years * Pregnant * Lactating * Exercise \>1.5 hours/week * Hepatitis B or C * Diabetes * History of liver disease * History of alcohol abuse * Severe hypertriglyceridemia (\>300 mg/dl) * Smokers * Anemia (Hemoglobin \<10mg/dl) * Not weight stable

Locations (1)

Washington University School of Medicine

St Louis, Missouri, United States

Outcomes

Primary Outcomes

Change in intrahepatic triglyceride (IHTG) content

Determine the effect of 4-week isocaloric diet high in high fructose corn syrup (HFCS) on IHTG content measured by magnetic resonance spectroscopy (MRS).

Time frame: 4 weeks

Hepatic lipid metabolism

Determine the effect of 4-week isocaloric diet high in HFCS on hepatic lipid metabolism \[de novo lipogenesis, very low density lipoprotein-triglyceride (VLDL-TG) and very low density lipoprotein-Apolipoprotein B100 (VLDL-ApoB) secretion rates\] by using stable isotope tracer methods.

Time frame: 4 weeks

Multi-organ insulin sensitivity

Determine the effect of 4-week isocaloric diet high in HFCS on multi-organ insulin sensitivity by using a one stage hyperinsulinemic euglycemic clamp procedure in conjunction with muscle and adipose tissue biopsies.

Time frame: 4 weeks

Uric acid metabolism

Determine the effect of 4-week isocaloric diet high in HFCS on uric acid metabolism by measuring post-prandial serum uric acid concentrations and using stable isotope tracer method.

Time frame: 4 weeks

Data from ClinicalTrials.gov

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