This is a multicenter, prospective, randomized, open-label study which compared two ventilation modes: spontaneous NAVA mode and spontaneous breathing with IPS mode (the latter is considered as the reference ventilatory mode) in patients admitted to the ICU for acute respiratory failure and ventilated with an endotracheal tube. NAVA mode allows to minimize patient-ventilator disharmony with acceptable tolerance and to preserve spontaneous ventilation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
129
Hopital L'Archet 1
Nice, Alpes Maritimes, France
Hopital de la CROIX ROUSSE
Lyon, Auvergne-Rhône-Alpes, France
Centre Hospitalier Lyon Sud
Lyon, Auvergne-Rhône-Alpes, France
Hopital PELLEGRIN
Bordeaux, Gironde, France
Groupe Hospitalier Sud - Hôpital Haut-Leveque - Maison du Haut-Leveque
Pessac, Gironde, France
Hôpital Dupuytren
Limoges, Haute Vienne, France
Hopital Saint-Eloi - CHU MONTPELLIER
Montpellier, Herault, France
Hopital Larrey- CHU D'ANGERS
Angers, Maine Et Loire, France
Hopital de la Cote de Nacre - CHU de CAEN
Caen, Normandy, France
Hopital d'Estaing
Clermont-Ferrand, Puy de Dome, France
...and 1 more locations
Evaluate the benefit of NAVA mode as compared to IPS mode in terms of duration of spontaneous ventilation 48 hours after inclusion.
The time spent in different modes of spontaneous ventilation (NAVA, IPS) and controlled ventilation (VAC controlled pressure) will be measured. The primary endpoint will be the proportion of patients remaining in spontaneous ventilation after the first 48 hours.
Time frame: Continuous recording during 48 hours following the intubation
Reduction of patient / ventilator disharmony, measured during the first 48 hours with the disharmony index
Time frame: Continuous recording during the first 48 hours
Real-time spent in NAVA mode and frequency of returns in a controlled mode (controlled ventilation VAC).
Feasibility of the initiation of mechanical ventilation in NAVA mode and feasibility of prolonged mechanical ventilation in NAVA mode
Time frame: Continuous recording during the first 48 hours
Earnings on the "breathing comfort"
Time frame: Continuous recording during the first 48 hours
Earnings on sleep architecture
Total sleep time; Number of arousals per hour; Duration of stage IV sleep ; Duration of Rapid Eye Movement (REM) sleep.
Time frame: Continuous recording during the first 48 hours
Tolerance
* Adverse events associated with the use of the device. * Incidence of ventilator-acquired pneumonia. * Duration of ICU stay. * Duration of hospital stay. * Mortality in the ICU. * Hospital mortality.
Time frame: Continuous for the duration of ICU stay, an expected maximum of 14 days
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