L-citrulline and Metformin in Becker's Muscular Dystrophy

Overview

The purpose of the study is to compare the effects of L-citrulline and metformin and their combination therapy on muscle function and force in patients with Becker muscular dystrophy (BMD).

This is a single center, not-randomized open study. The study medication consists of L-citrulline and metformin administered orally; 5g citrulline and 500mg metformin tablets will be given 3 times daily. Half of the patients will be treated with metformin during the first 6 weeks of the study. The other patients will receive initially L-citrulline for 6 weeks, before all patients will be treated with the combination therapy (metformin and L-citrulline) for another 6 week period. The study lasts 12 weeks and includes the screening visit and 3 further visits at baseline, week 6 and week 12.

Conditions

Interventions

Eligibility

Locations (1)

Outcomes