This study aimed to investigate the effect of low intensity cathodal direct current on the release of plasma vascular endothelial growth factor (VEGF) and nitric oxide (NO) in diabetic foot ulceration.
Twenty type 2 diabetic patients with foot ulceration and 13 age-matched healthy subjects were enrolled. Patients were randomly assigned to electrical stimulation (ES, n=10) or sham ES (placebo, n=10) groups. ES group received cathodal direct current for 1 h/day, 3 days/week, for 4 weeks (12 sessions). Blood sample was collected for VEGF and NO measurement in the first and last treatment sessions before and after intervention. Wound surface area (WSA) and skin temperature were measured at 1st, 6th, and 12th session.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
Direct current ES
the intervention procedure was the same as that the ES group, but the current intensity was zero
Physical Therapy Department, Faculty of Medical Sciences
Tehran, Iran
The plasma level of VEGF(pg/ml) and NO (microM)
Time frame: prior to the 1st electrical stimulation session(day 1) and 1 hour later, and prior to the 12th electrical stimulation session(day 26) and 1 hour later
skin temperature (degree of centigrade)
Time frame: prior the 1st electrical stimulation session (day 1) and 1 hour later
skin temperature (degree of centigrade)
Time frame: prior the 6th electrical stimulation session (day 12) and 1 hour later
skin temperature (degree of centigrade)
Time frame: prior the 12th electrical stimulation session (day 26) and 1 hour later
Wound surface area(cm2)
Time frame: on day 1, 12, and 26
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