Antioxidant Effect of Aged Garlic Extract

N/ACompletedNCT02019368

Hiroshima University60 enrolled

Overview

This is a randomized, double-blind, placebo controlled, crossover study to determine the antioxidant effect of aged garlic extract. This study will also compare the oxidative status in heavy smokers with that in non-smokers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Heavy Smoker or Non-smoker

Interventions

PlaceboDIETARY_SUPPLEMENT

Aged garlic extractDIETARY_SUPPLEMENT

Eligibility

Sex: MALEMin age: 40 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Smoking (at least 20 cigarettes per day) or non-smoking (more than 20 years) Exclusion Criteria: * Under medication for chronic disease * Garlic allergy * Engaging in vigorous exercise * Taking drugs or functional food that may possess antioxidant property * Participation in any clinical trial within 90 days of the commencement of the trial * Renal or hepatic dysfunction * Heart disease

Locations (1)

Hiroshima University

Hiroshima, Hiroshima, Japan

Outcomes

Primary Outcomes

Urinary 8-hydroxydeoxyguanosine (8-OHdG)

Time frame: Every 4 weeks (Overall 12 weeks)

Secondary Outcomes

High sensitive CRP

Time frame: Every 4 weeks (Overall 12 weeks)

Blood pressure

Time frame: Every 4 weeks (Overall 12 weeks)

Indices of the second derivative of photoplethysmogram (SDPTG)

Time frame: Every 4 weeks (Overall 12 weeks)

Data from ClinicalTrials.gov

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