Retrospective evaluation on the effect of splenic irradiation on clinical and hematological response and toxicity in patients with chronic lymphatic leukaemia (CLL).
The study will include patients with CLL treated with splenic irradiation in Maastro Clinic, Maastricht, The Netherlands, Maxima Medisch Centrum Veldhoven/Catharina hospital, Eindhoven, The Netherlands and Modena hospital, Modena, Italy. Data will be collected from patient records in an uniform database. Data will include demographic data, CLL stadium (RAI and Binet) at diagnosis and at the time of irradiation treatment, clinical data at diagnosis (haematology), splenic irradiation data, follow-up data such as date of progression or death
Study Type
OBSERVATIONAL
Maastro Clinic
Maastricht, Netherlands
Clinical and haematological response
Clinical and haematological response measured by number of leucocytes and thrombocytes during and after irradiation. Hemoglobin and size of spleen during and after irradiation in the time period 2000 tot 2013
Time frame: 13 years
Progression of chronic Lymphatic leukaemia
Progression of chronic Lymphatic leukaemia after irradiation in the time period 2000 tot 2013
Time frame: 13 years
Death
Patients will be followed from the time of splenic irradiation to death in the time period of 2000 tot 2013
Time frame: 13 years
Toxicity of splenic irradiation
Toxicity of splenic irradiation during and after irradiation measured by evaluating clinical toxicity based on the CTCAE version 3.0 during and after irradiation (2000 to 2013)
Time frame: 13 years
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