The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.
The primary hypothesis is that obese adolescents have a disturbed balance of hormones associated with appetite regulation with less suppression of ghrelin and attenuated stimulation of GLP-1 secretion in response to meal intake compared to lean normal weight controls. A second aim of the study was to test which gastrointestinal peptides are most associated with insulin resistance.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
30
whole wheat bread (68 g), butter(10 g), ham (25 g); chocolate cream (90 g); orange juice (200 mL)
whole wheat bread (68 g), butter(10 g), ham (25 g); chocolate cream (90 g); orange juice (200 mL)
University Hospital Basel, Division of Gastroenterology and Hepatology
Basel, Switzerland
Comparison of gastrointestinal peptide secretion in normal weight and obese adolescents
Relation of GLP-1 release to insulin secretion in normal weight and obese adolescents
Time frame: 2 hours blood sampling
Association between gastrointestinal peptides and insulin release
Dynamics of gastrointestinal peptide secretion including Tmax and Cmax
Time frame: 2 hours blood sampling
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