Cerebral Microembolism During Hemodialysis

N/ACompletedNCT02021045

Medical University of Vienna40 enrolled

Overview

There is increasing evidence that renal replacement therapy (= continuous veno-venous hemodialysis) generates cerebral microembolism which is detectable on transcranial Doppler ultrasound. The aim of this study is to monitor patients with transcranial Doppler under two conditions: during hemodialysis and in a hemodialysis-free interval (in each period cerebral embolic load is detected during 30 minutes). The study hypothesis is that during hemodialysis the cerebral embolic load is significantly higher than in the hemodialysis-free interval.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Complication of Dialysis Thrombus Due to Renal Dialysis Device, Implant, or Graft Cerebral Embolism

Interventions

Renal hemodialysis (Fresenius 2008K, Bad Homburg, Germany)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Renal replacement therapy (continuous veno-venous hemodilalysis) on the in-house intensive care unit * Age \> 18yrs and \< 90yrs Exclusion Criteria: * Absent informed consent * Preexistent neurological morbidity * Neurocognitive disturbances * Carotid artery stenosis \> 70% * Patent foramen ovale * Treatment with other extracorporeal devices * Cardial pathology (valvular heart disease, prosthesis, endocarditis) * Pregnancy, drug abuse * Inclusion in an other clinical study * Allergy against materials of the medical device used in the study (transcranial Doppler) or temporal skin/bone lesions

Outcomes

Primary Outcomes

Quantity of cerebral embolic load

Cerebral embolic load is measured in a 30 minutes-interval during hemodialysis and in a hemodialysis-free interval.

Time frame: 30 minutes

Secondary Outcomes

Quality and laterality of cerebral embolic load

Quality (solid vs. gaseous) and laterality (left vs. right hemispheric dominance) of cerebral embolic load is measured in a 30 minutes-interval during hemodialysis and in a hemodialysis-free interval.