The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
55
Glucose uptake is measured by oral glucose tolerance test and euglycemic clamp
Resting metabolic rate is measured by indirect calorimetry after an over-night fast
Sodium nitrite or saline was infused at escalating doses at a rate of 1, 10 or 100 nmol kg-1 min-1 (10 minutes per dose) in a randomized, double blinded cross-over fashion
Karolinska Institutet
Stockholm, Sweden
Resting metabolic rate
Resting metabolic rate, measured after overnight fast using indirect calorimetry
Time frame: day 4
Thyroid hormone status
Time frame: day 4
Glucose uptake
Glucose uptake measured with oral glucose tolerance test and euglycemic clamp
Time frame: day 4
Nitrite infusion
Effect on resting metabolic rate when infusing escalating intravenous doses of sodium nitrite or saline solution
Time frame: 30 minutes
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