Branched Chain Aminoacid Supplementation in Patients With Liver Cirrhosis

Phase 4CompletedNCT02023229

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran68 enrolled

Overview

Malnutrition is a frequent complication in patients with liver cirrhosis. Most patients have decreased dietary intake due to ascites, hepatic encephalopathy and pro-inflammatory cytokines. We hypothesized that branched chain aminoacids can improve nutritional status and delay episodes of hepatic encephalopathy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Liver Cirrhosis

Interventions

Branched-chain aminoacidsDIETARY_SUPPLEMENT

High-fiber high protein dietOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: Ambulatory patients Patients with confirmed diagnose of liver cirrhosis Patients classified as Child-Pugh A or Child Pugh B Exclusion Criteria: Acute or chronic renal failure Pregnancy Overt hepatic encephalopathy

Locations (1)

Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"

Mexico City, Mexico

Outcomes

Primary Outcomes

Nutritional status

Assessed by bioelectrical impedance vector analysis and mid-arm muscle circumference

Time frame: At time of recruitment

Secondary Outcomes

Hepatic Encephalopathy

Time frame: At time of recruitment

Data from ClinicalTrials.gov

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