Single Dose of Atorvastatin and Circulating Endothelial Microparticles

Phase 4UnknownNCT02023892

Sun Yat-sen University30 enrolled

Overview

Healthy subjects take single dose of 80mg atorvastatin, then measured their circulating endothelial microparticles and flow-mediated vasodilation in the brachial artery by ultrasound at different time points.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Endothelium Hydroxymethylglutaryl-CoA Reductase Inhibitors

Interventions

atorvastatinDRUG

placeboDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy youth Exclusion Criteria: * acute pathologies * familial history of cardiovascular disease * smoking or drinking alcohol

Outcomes

Primary Outcomes

change of circulating endothelial microparticles

Time frame: from 1h to 24h after taking atorvastatin

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.