The investigators hypothesize that children receiving human milk will maintain a greater diversity of helpful bacteria in their gut and have lower levels of inflammatory proteins in the blood compared with children not receiving human milk.
The investigators hypothesize that the gut microbiota during bone marrow transplant could be influenced by administration of enteral donor breast milk. This study will attempt to address this hypothesis, by feeding donor breast milk to young children undergoing transplant, and serially comparing the gut micobiota in children receiving human milk, with those receiving conventional feeding.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
11
* A registered dietician will supervise milk provision, and additional calories will be provided by addition of the supplement Prolacta. To make 28 kcal/oz milk, 40 ml of Prolacta will be mixed with 60 ml human milk to make a total volume of 100 ml. * If a nursing mother enrolls on the study, maternal and not donor milk will be given in the maximum volume possible, with Prolacta supplementation if clinically indicated and recommended by the registered dietician.
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
Percentage of lactobacillales
Bar charts to indicate types and percentage of bacteria in stool samples - will quantify the bacterial diversity using the Shannon index and bacterial chaos using the Bray-Curtis time index.
Time frame: 21 days after transplant
Levels of pro-inflammatory cytokines
Mean fold increase above baseline for each cytokine will be calculated and compared to controls
Time frame: Weekly during study course; up to approximately one year
Incidence of bacteremia
Frequency of bacterial sepsis to be compared against controls
Time frame: through day 14 post transplant
Incidence of graft versus host disease (GVHD)
Frequency of GVHD will be compared to controls
Time frame: through study course; approximately one year
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