IVF Hyper-responders: Oocyte Vitrification Compared With Embryo Freezing

N/ACompletedNCT02026193

Rambam Health Care Campus11 enrolled

Overview

The chances to achieve pregnancy after retrieving \>15 oocytes are not good, probably because of bad effect on the endometrium (uterine inner lining). Therefore, in most such cases the investigators prefer to freeze all embryos, and transfer in a thaw cycle. With the introduction of oocyte vitrification (very fast cooling) technology, a new option emerged: to freeze un-fertilized eggs, to be fertilized and used later in a thaw cycle. The purpose of this study is to compare the outcome of these two approaches.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Infertility

Interventions

oocyte vitrificationPROCEDURE

embryo freezingPROCEDURE

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * IVF patients * ovulation trigger with Decapeptyl 0.2 mg because of ovarian hyper-response: E2 on trigger day .12,000 pmol/l and/or \>15 oocytes. * Normal uterus Exclusion Criteria: * \<20% fertilization rate

Locations (1)

IVF Unit, Rambam medical Center

Haifa, Israel, Israel

Outcomes

Primary Outcomes

Fetal Heart Activity 1 Month Post Embryo Transfer

Fetal heart activity as demonsrated by vaginal ultrasound 1 month post embryo transfer

Time frame: 1 month after embryo transfer

Data from ClinicalTrials.gov

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