Sudden Hearing Loss Multi-center Clinical Trial

Inclusion Criteria: * Older than 18 years, less than 60 years old; * patient with unilateral or bilateral（occured successively) acute sensorineural hearing loss(ASNHL) with onset 72hours or less ago. Mean hearing loss compared with the unaffected contralateral ear of at leat 60 dB; * Primary presentation within 2weeks; standard treatment for 2 weeks; * After 2weeks of standard treatment, sensorineural hearing loss (SHL) curative effect evaluation damaged frequencies \>/=30 dB better than before; * Written informed consent before participation in the study. Exclusion Criteria: SYSTEMIC DISEASE * History of tuberculosis or positive purified protein derivative (PPD); * Insulin-dependent diabetes mellitus; * Hypertension, poor control of BP(SBP/DBP)\>=140mmHg); * History of rheumatic disease, e.g. rheumatoid arthritis, scleroderma, lupus, etc; * Serious psychiatric disease or psychiatric reaction to corticosteroids; * History of heart disease or transient ischemic attacks(TIAs); * Prior treatment with chemotherapeutic or immunosuppressive drugs; * Pancreatitis; * Active peptic ulcer disease or history of gastrointestinal bleeding; * History of HIV, Hepatitis B or C; * Chronic kidney failure; * Alcohol abuse; * Active shingles; * Severe osteoporosis or non-surgical aseptic necrosis of the hip; * Without contraindication with glucocorticoid, ginaton, Batroxobin. OTOLOGIC DISEASE * History of Meniere's disease; * History of chronic ear infection; * Prior history of sudden sensorineural hearing loss (SSNHL); * History of fluctuating hearing loss.