Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome

Inclusion Criteria: 1. age 18-75 yrs 2. patients with Irritable Bowel Syndrome (IBS) according to ROME III criteria 3. BMI 18-25 4. a- no intestinal organic diseases b- no intestinal infection c- no history of chronic gastrointestinal and colorectal diseases d- no intestinal major surgery 5. no regular use of antibiotics, anti-constipation and anti-diarrhea, immune suppressors, metoclopramide, cisapride, diphenoxylate, opium and non-steroidal anti-inflammatory drugs 6. no pregnancy and lactation 7. not athlete or bed rest 8. no history of breast cancer in herself or her family 9. no severe psychosis Exclusion Criteria: 1. a- use of soy isoflavones or vitamin D one year before the study b- use of soy milk or soy nuts during study 2. diet changes during study 3. use of artificial sweetener 2 days before study 4. no desire to complete the study 5. adverse effect of supplement 6. pregnancy during study