Novel MRI Techniques in the Evaluation of Pulmonary Vascular Disease

Phase 2CompletedNCT02026531

Sheffield Teaching Hospitals NHS Foundation Trust9 enrolled

Overview

The diagnosis of a patient with pulmonary hypertension (PH) requires many investigations. At present cardiac catheterisation is the cornerstone investigation in these patients where it is used to establish disease severity and estimate prognosis. It is an invasive procedure which is expensive and not without risk to the patient. Despite the multitude of tests performed, identifying those patients with PH who have a poor diagnosis can be difficult. The aim of this study is to improve the assessment of patients with PH using novel magnetic resonance techniques.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Pulmonary Hypertension

Interventions

3-Helium gasOTHER

3-Helium gas for MRI contrast

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All cases referred to the clinic for assessment for possible pulmonary hypertension. Exclusion Criteria: * patients with a cardiac pacemaker or retained temporary pacing wire * patients with aneurysm clip * non MRI compatible heart valve prosthesis * intra orbital metalic foreign body * pregnancy * metal prosthesis/spinal rods * retained shrapnel * cochlear implants/bladder stimulator

Locations (1)

Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital

Sheffield, South Yorkshire, United Kingdom

Outcomes

Primary Outcomes

pulmonary artery diameter (mm)

Three-dimensional MRI imaging will be used to acquire cardiac dimensions and anatomical ventilation distribution as well as regional partial pressures of oxygen in the lungs.

Time frame: up to 3 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.